A while back i bumped into a problem with a DPM console that all of a sudden started to crash. The situation was only affected for one user and not other DPM administrators so the first conclusion was that this is user-specifics.
DPM (and other System Center products) creates a version of the MMC in the user profile. If this version is damaged or corrupt you will get an error stating
“MMC cannot open the file… This may be because the file does not excist, is not an MMC console, or was created by a later version of MMC. This may also be because you do not have sufficient rights to the file.”
To resolve this you simple need to delete the version file of the MMC. This file is located @ “